Frontiers Growth hormone insulin like growth factor I axis in health and disease states: an update on the role of intra portal insulin How GHK Peptide Works Signaling GHK acts as a switch for skin repair: Interacts with adenosine receptors reduces inflammation Activates MAPK ERK, PI3K Akt, TGF pathways Stimulates fibroblasts & keratinocytes boosts collagen, elastin Synergy of GHKCu and hyaluronic acid on collagen IV upregulation via fibroblast and exvivo skin tests Jiang 2023 Journal of Cosmetic Dermatology Wiley Online Library of the effects of GHK on pulmonary fibrosis. GHK exerts anti fibrotic Download Scientific Diagram